Kurongwa kwechirwere checorticobasal kwakavakirwa pa biomarker 

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Corticobasal syndrome (CBS) chirwere chinotsanangurwa nekiriniki chine matambudziko ekufamba-famba uye zviratidzo zve cortical, izvo zvinogona kukonzerwa nemhando dzakasiyana dzezvirwere zvinotsanangurwa ne neuropathologically. CBS inowanzobatanidzwa ne 4-repeat tauopathies (4RTs), kusanganisira progressive supranuclear palsy (PSP) uye corticobasal degeneration, kana mixed 3-repeat / 4-repeat tauopathy Alzheimer's disease (AD). Zvisinei, Lewy-type α-synucleinopathies (LTS), TDP-43 proteinopathies, kana mixed pathologies zvinogonawo kuonekwa seCBS. Asi kukosha kwekiriniki kwezvirwere zvakasiyana zviri muCBS hakusati kwanyatsonzwisiswa. Nokudaro, chidzidzo chiripo parizvino chaive nechinangwa chekuisa varwere veCBS muzvikamu zvemamorekuru nekushandisa biomarkers ye amyloid (Aβ), Tau, uye α-synuclein (αSyn), zvichibvumira subclassification in vivo. 

Takaita ongororo yeboka revanhu makumi mashanu (50 CBS) yaisanganisira varwere veCBS vakaongororwa pachipatara cheLMU University Hospital Munich. Ongororo yeBiomarker yaisanganisira kuyerwa kwecerebrospinal fluid (CSF) yeAβ42 neAβ42/40 ratios, [18F]Flutemetamol β-amyloid-PET, [18F]PI-2620 Tau-PET, uye CSF αSyn seed amplification assays. Neurofilament light chain (NfL) muCSF yakashanda sechiratidzo chisina kujeka chekuora kwetsinga. Biomarker positivity kana negativity yakabvumira kupatsanurwa kweCBS mumapoka matanhatu, zvichiratidza zvirwere zvechokwadi zvichibva pakubatanidzwa kweAβ, Tau, uye αSyn.  

Zvatakawana zvakaratidza kuwanda kweTau positivity, 90% yevarwere veCBS vaine Tau-positive, ukuwo Aβ neαSyn positivity zvakaonekwa mu28% ne24% yezviitiko, zvichiteerana. Kupatsanurwa kwezvikamu nezvirwere zvakatsanangurwa nebiomarker kwakaratidza kuti 52% yezviitiko zveCBS zvaienderana ne4RT, 18% neAD, 10% nekusangana kweAD neLTS, 10% ne4RT neLTS, uye 4% neLTS dzakaparadzaniswa. 6% yakaramba isina kurongwa. αSyn-positivity yaive yakajairika muzviitiko zveCBS zvine AD inofungidzirwa (36%), zvichienzaniswa neizvo zvine 4RT inofungidzirwa (16%). Mukurapa, Aβ-positivity yaive yakabatana nekusagadzikana kwepfungwa kwakasimba muMontreal Cognitive Assessment uye Dementia Apraxia Test. Tau positivity yaive yakabatana nezviratidzo zvakanyanya zvekufamba asi haina kuratidza mhedzisiro yakakosha pakukura kwechirwere. Kusiyana neizvi, varwere vane αSyn positive vakaratidza zviratidzo zvishoma zvekufamba kwemuviri, mamakisi ePSP akaderera, uye kufambira mberi zvishoma nezvishoma nekufamba kwenguva, pamwe chete nemazinga eCSF NfL akaderera zvakanyanya. 

Chidzidzo chedu chinosimbisa kusiyana kwemamorekuru eCBS, zvichiratidza mukana wekuti biomarker-based stratification ivandudze kunyatsoongorora uye kutungamira kurapwa kwakanangana. 

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