BHUKU 29, CHIKAMU 4 • ZVITA 2025.
Kuchinja kwemasero kwe STN neurons nenzira dzakasiyana-siyana kunobatsira kuponesa Parkinsonian motor motor symptoms.
Kuhwina Mubairo weVadiki pa2025 MDS Congress kwaive chimwe chezvinhu zvaiitika muhupenyu hwangu. Kubva pandakatanga kutora chikamu muMDS muStockholm muna 2014, ndakaona vaongorori vechidiki vakawanda vakanaka vachiwana rukudzo urwu, uye mumakore apfuura, ndakaonawo vakapihwa mibairo vachikura kuva vaongorori vanotungamira vanogadzira munda uyu kupfuura mugumo wemazuva ano. Kugamuchira mubairo uyu kwainzwa sekunge kunoshamisa; pakutanga handina kukwanisa kutenda chiziviso ichi, uye ndinoyeuka ndichibvunza kana paine chikanganiso uye kana chaive chechokwadi. Chikamu chakanakisa chekugamuchira mubairo uyu kwaive kuunza mudzimai wangu nemwanakomana wangu kuhurukuro dzemubairo, uye ndakawana mukana wekuzivisa basa rangu kumhuri yangu.
Ndinoyeuka zuva randakasarudza neurology sebasa rangu remangwana. Munguva yangu yekudzidzira muDhipatimendi reAnesthesiology, ndakaona kuvhiyiwa kwangu kwekutanga kweDBS muna Chikumi 2010. Ndichiri kurangarira zvakajeka nguva iyoyo: Varwere vakamutswa panguva yekuvhiyiwa, uye ndakaona mhedzisiro inoshamisa yeDBS pakudengenyeka kwevarwere vane chirwere cheParkinson. Murwere wacho akachema, uye handina kutarisira nguva yakadzama kudaro sezvo ndakanga ndakagara kumashure kwemuchina weanesthesia. Chiitiko chimwe chete ichocho chakaita kuti ndide kunzwisisa matambudziko ekufamba zvakadzama uye chakandikurudzira kutsvaga varayiridzi vaigona kunditungamira. Kusangana naPurofesa Beomseok Jeon (BJ) kwakakosha; kudzidzisa kwake kwakagadzira nzira yangu uye kwakandizivisa nyika yezvirwere zvepfungwa zvekiriniki uye matambudziko ekufamba. Semunhu anogara muuropi, ndakawana mukana wekuona varwere vazhinji vePD vane DBS, uye ndakatanga kuona mabhenefiti anoshamisa ekukurudzira, munguva pfupi nerefu. Pakutanga, ndakatoshamisika kuti nei taifanira kudzidza mashandiro eDBS nepo yaitoshanda zvakanaka mukiriniki. Asi nekufamba kwenguva, ndakaona kuti taisanzwisisa zvakawanda nezve neurophysiology iri pasi payo.
Kusazadzikiswa kwechido ichi kwakaita kuti ndiite PhD yenguva yakazara paKorea Advanced Institute of Science and Technology (KAIST), kwandakanyura muhurongwa hwepfungwa hwe basal ganglia ndichishandisa matekinoroji matsva akadai se single-unit electrophysiology, optogenetics, uye in-vivo calcium imaging. Basa rangu rakanangana nekunzwisisa mashandiro e basal ganglia kuburikidza nekupatsanurwa kwema circuits ayo.
Pandakadzokera kuchipatara mushure mekupedza PhD yangu, ndakatanga kurapa varwere vane chirwere cheParkinson ndichishandisa deep brain stimulation (DBS) semushandi wekiriniki ari pasi paProfessor BJ. Neruzivo rwakawanda, ndakatanga kuona zvinhu zvandaisambofarira kare. Kuwedzera pakuona kuvandudzwa kukuru kwekiriniki, ndakasanganawo nemhedzisiro isiri yekufamba kwemuviri iyo vamwe varwere vanosangana nayo. Pandakaramba ndichiona varwere vachitambura nemhedzisiro yekufunga kana yemanzwiro mushure me STN DBS mbiri, kuda kwangu kuziva kwakawedzera - pakupedzisira kukava chivimbo: Kuti tivandudze mhedzisiro, kuderedza mhedzisiro, uye kugadzira chizvarwa chinotevera chekurapa kwe neuromodulation, tinofanira kutanga tanzwisisa macircuit chaiwo atiri kugadzirisa. Panguva iyi ndipo pakatanga kuumbwa pfungwa yepurojekiti yangu yakahwina mubairo. Humbowo hwaibuda hwakaratidza kuti subthalamic nucleus (STN) yaive yakasiyana zvikuru kupfuura zvaitendwa kare. Nekuda kwekuwanikwa kwaJinny Kim, wandaishanda naye kubva kuKIST, taigona kunzwisisa ma cellular subtypes ari mukati me STN. Takafungidzira kuti mhando dzemasero chaiwo (ma neuron anotsanangura parvalbumin) anogona kunge ari kunyanya kukanganiswa nezviratidzo zvekufamba kwemuviri muchirwere cheParkinson zvichibva pakupararira kwenzvimbo uye hunhu hwemagetsi.
Mumakore anoda kusvika matatu ekushanda, tichishandisa mamodheru embeva eParkinsonian akawanda uye maturusi epamusoro ekugadzirisa macircuit, ini nechikwata changu takawana humbowo hunogutsa hwekuti kugadzirisa maneuron eparvalbumin nenzira yakasarudzika kunogona kuponesa zviratidzo zvekufamba kweParkinsonian, ukuwo kugadzirisa mamwe mapoka ari mukati meSTN hakuna kuunza mabhenefiti mukushomeka kwekufamba kwemodheru muPD model. Izvi zvakasimbisa pfungwa yekuti neuromodulation yeramangwana inogona kunge yakanyatsojeka, ichinanga kune mamwe ma cellular subtypes kuti iwedzere kubatsira uku ichideredza migumisiro yakaipa. Kana ikabvumidzwa mumamodheru ese uye ikawedzerwa nematekinoroji matsva, ruzivo rwakadaro runogona kutungamira masisitimu eDBS echizvarwa chinotevera anokwanisa kukurudzira chete ma microcircuits ekurapa zvakanyanya uku achichengetedza ayo anobatsira mumhedzisiro yakaipa yekuziva kana yemanzwiro. Izvi zvinogona kuumba patsva maitiro atinoita DBS programming mune ramangwana.
Kugamuchira Mubairo weVadiki hakusi kungori chiitiko chakakosha chete, asiwo chiyeuchidzo chekuti nei kuda kuziva kwesainzi uye kutsungirira zvichikosha kudaro. Ndinovimba rwendo rwangu runokurudzira vamwe vaongorori vechidiki kuti vatevere mibvunzo yavo nechido. Dzimwe nguva, nguva imwe chete yekukurudzirwa - senge kuvhiyiwa kwangu kwekutanga kweDBS - inogona kushandura basa. Uye dzimwe nguva, zviroto zvinozadzika zvechokwadi. Ndinoda kutenda vese vandinoshanda navo nenhengo dzerabhoritari, kunyanya Purofesa BJ nekutungamira kwavo mubasa rangu rese. Uye pakupedzisira, ndinoda kuratidza kuonga kwangu kwechokwadi kumhuri yangu nerutsigiro rwavo rusingaperi.
Unogona kuona marekodhi emusangano wegore ra2025, kusanganisira hurukuro dzeMubairo weVana, kusvika Kubvumbi 30, 2025.
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