BHUKU 29, CHIKAMU 4 • ZVITA 2025.
Kuora Kwemuviri MuMasisitimu Akawanda Kuora Kwemuviri Kunoenderana Nemaitiro eMitochondrial neOligodendrocytic
Kugamuchira Mubairo weVadiki pa2025 MDS Congress iropafadzo huru, uye ndinotenda zvikuru nekuzivikanwa uku. Senyanzvi yezveuropi ine chido chakasimba mukufungidzira neuroimaging yeParkinsonian syndromes isingawanzoitiki, chinangwa changu chagara chiri chekushandisa imaging kwete sechishandiso chekuongorora chete, asi sewindo rekuona maitiro ezvehupenyu anokonzera matambudziko aya akaomarara. Mubairo uyu unoratidza kukosha kwebasa iri uye mukana wemifananidzo yepamusoro inobatsira zvikuru mukunzwisisa kwedu kuora kwetsinga.
Ndakadzidzira neuroradiology paPitié-Salpêtrière Hospital muParis, ndichiteverwa nenyanzvi yekutsvagisa mukurapa kwemifananidzo yezvekurapa. Pakupedzisira, kufarira kwangu mashandiro ari kukonzera zvirwere zveParkinson kwakaita kuti nditsvage PhD yakatarisana nekushandisa multimodal MRI nekudzidza kwemuchina kuti ndiwedzere kuongororwa kwepakutanga uye kujekesa pathophysiology yezvirwere zvakanangana nechirwere. Ndiri kuwedzera basa iri sechikamu che postdoctoral fellowship yangu paNeuro, McGill University, Montreal. Basa rangu razvino rinoshandisa ruzivo rwangu rwekiriniki nerwetsvagiridzo, ndichisimbisa kuti kufungidzira kunogona sei kubatanidza ongororo dzekiriniki nemaitiro emamorekuru ari mukati meuropi.
Muchidzidzo chakacherechedzwa nemubayiro uyu, une musoro unoti "Atrophy in Multiple System Atrophy Relates to Mitochondrial and Oligodendrocytic Processes," chinangwa chedu ndechekunzwisisa zviri nani hwaro hwe brain atrophy in multiple system atrophy (MSA). Kunyangwe MSA iri α-synucleinopathy inozivikanwa zvikuru inotarisa ma oligodendrocytes, pathophysiology yayo ichiri kunzwisiswa zvisina kukwana. Neuroimaging inopa mukana wakasiyana wekuongorora nzira idzi pasina kupindira.
Boka redu raisanganisira varwere makumi matanhatu nevashanu vane MSA uye 181 vane hutano hwakanaka. Takatanga taongorora maitiro e brain atrophy tichishandisa structural MRI, iyo yakaratidza kubatanidzwa kunotarisirwa kwe cerebellum, pons, uye basal ganglia, kunyanya putamen. Chinoita kuti chidzidzo ichi chive chitsva ndechekuti takabatanidza sei shanduko idzi dzechimiro nenzira dziri pasi pemamorekuru nekubatanidza data reMRI neruzivo rwe transcriptomic kubva kuAllen Human Brain Atlas, sosi yakakura ye gene-expression inobva ku postmortem healthy brains. Tichishandisa partial least squares regression, takaona zvikamu zve gene-expression zvaienderana ne MSA-specific atrophy pattern. Gene set enrichment analysis yakaratidza kuti nzvimbo dze atrophic dzakaratidza kuwanda kwemajini ane chekuita nebasa re mitochondrial uye oligodendrocytic processes, nzira mbiri dziri pakati peMSA pathology. Chinonyanya kukosha ndechekuti, patakadzokorora ongororo iyi muPD cohort, mitochondrial gene enrichment yakaonekwa chete muMSA, ichitsigira chirwere chayo. Takaenderera mberi nekubatanidza nzira iyi nema PET receptor-density maps anobva kudata guru, riripo pachena. Nekubatanidza kugoverwa kwemareceptor nemapatani eMSA-related atrophy, takaongorora kuti ma neurotransmitter nema cellular receptor systems angachinjwa sei kana kuti anogona kuva panjodzi munzvimbo dzakabatwa nechirwere ichi. Iyi nzira yekubatanidza mifananidzo nemamorekuru inoratidza kuti MRI yakajairika, kana yakabatanidzwa nemaseti edata e normative molecular, inogona kupa ruzivo rwakakosha nezve biology.
Chimwe chezvinhu zvinonyanya kukosha mubasa iri ndechekuti rinosimbisa kushanda kwezviratidzo zveMRI. Kuratidza kuti shanduko dzemaumbirwo emuviri dzinoenderana nekusagadzikana kwe mitochondrial ne oligodendrocytic kunotiswededza pedyo nekugadzira mifananidzo ye biomarkers isingangoone chirwere chete asiwo inoteedzera kufambira mberi kana mhinduro yekurapa.
Ndichitarisa mberi, ndinoronga kuwedzera tsvakiridzo iyi. Pari zvino ndiri kutarisa pa ultra-high-field MRI pa 7 Tesla, iyo inopa kugona kwakanaka kwekuona nzvimbo uye inogona kutibvumira kuona shanduko dzisingaoneki kare dzatisati tasvika. Imwe nzira inovimbisa ndeye kufungidzira kwemutsara wemusana, nzvimbo isina kuongororwa zvakakwana asi yakakosha muzvirwere zveParkinsonian. Kusimbiswa kukuru kwave kuri pauropi, asi maitiro akakosha ezvirwere anoitikawo padanho remusana, uye kufungidzira kwepamusoro kunogona kubatsira kuaburitsa pachena.
Kuwana Mubairo weVana Vadiki iropafadzo uye chishuwo chekuramba tichiita basa iri. Ndinovimba kuti kuedza uku kuchabatsira mukuvandudza kuongororwa kwechirwere nekukurumidza, kunatsiridza zviratidzo zvechirwere, uye pakupedzisira kudzamisa kunzwisisa kwedu MSA nezvimwe zvirwere zvine chekuita nazvo.
Unogona kuona marekodhi emusangano wegore ra2025, kusanganisira hurukuro dzeMubairo weVana, kusvika Kubvumbi 30, 2025.
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