Ko carbon monoxide shoma inogona kurapa chirwere cheParkinson here?

---

Sei vanosvuta vachiita sevane njodzi shoma yekubatwa nechirwere cheParkinson? Kubatana kwakasimbiswa pakati pekusvuta nechirwere cheParkinson kwave kuchizivikanwa kwemakumi emakore, kunyange zvazvo nzira chaiyo ichiri kuzivikanwa. Pasinei nemakakatanwa, zvidzidzo zvikuru zvezvirwere zvakaratidza kuwanda kwechirwere cheParkinson muvanosvuta. Pakati petsananguro dzinoverengeka dzinogona kuitika, fungidziro inokonzeresa ndeyekuti mwero wakaderera wecarbon monoxide unogara kwenguva refu unogona kunge uri chikamu chekubatana uku.

Pfungwa iyi yakakurudzira vaongorori kuti vaongorore zvimwe zvidzidzo zvemhuka vachiongorora mhedzisiro inogona kuitika yecarbon monoxide kudzivirira tsinga. Pakati pavo, Stephen Gomperts, PhD paMassachusetts General Hospital (MGH), Harvard Medical School yakaratidza nzira dzinogona kushandiswa kuderedza kuora kwetsinga muchirwere cheParkinson. Izvi zvinosanganisira mhedzisiro ye cytoprotective, anti-inflammatory, uye anti-apoptotic, pamwe nekuwedzera mitophagy. Mumakonzo, Dr. Gomperts nevamwe vake vakaratidza kudzikira kwe alpha-synuclein pathology uye kurasikirwa nedopamine cell mushure mekusangana ne carbon monoxide ine dose shoma pamazinga anowanikwa nevasvuta.

"Zvatakawana zvinoratidza kuti nzira dzemamorekuru dzinoshandiswa necarbon monoxide shoma dzinogona kuderedza zvirwere zveParkinson," akadaro Gomperts. "Zvinoshamisa kuti, zvidzidzo zvakawanda zvekiriniki zvechikamu chekutanga nechikamu chechipiri kunze kweParkinson's disease zvakaratidza kuchengetedzeka kwecarbon monoxide pamatanho mashoma akadzidzwa pano."

Vachivakira pamhedzisiro iyi yekutanga yakanaka, vaongorori vakatsigira Hillhurst Biopharmaceuticals mukugadzira bvunzo yePhase 2A inoongorora kuchengetedzeka uye kushanda kwecarbon monoxide inonwiwa nemuromo muchirwere cheParkinson. Chidzidzo cheLiquid Carbon Monoxide (HBI-002) Liquid Low dose yekuongorora kuchengetedzeka kwayo, kushivirira, pharmacokinetics, uye biomarkers muchirwere cheParkinson (LoCaMoTE-PD) - chakatungamirwawo naDr. Michael Schwarzschild kubva kuMGH uye vachishandisa chimiro chePSG, pamwe chete neHillhurst Biopharmaceuticals, chinangwa ndechekunyoresa varwere vanosvika makumi matatu nevatanhatu vari mumativi matatu (carbon monoxide yakaderera, yepakati - inosvika pakusangana neCO muvanhu vanosvuta vane chiedza kusvika kune vane mwero, uye placebo). Vatori vechikamu vachadya HBI-002, mushonga weliquid wecarbon monoxide, kwemazuva gumi nemana nekutevera uye kuunganidzwa kwebiomarker yakawanda kusvika pazuva rechi44.

Mhedzisiro huru ndeye kuchengetedzeka uye kushivirira kweHBI-002. Mhedzisiro yechipiri ndeyekuongorora pharmacokinetics yeHBI002. Zviratidzo zvakawanda zve biomarkers zvinotarisa pakuyera kwekubatanidzwa kwechinangwa uye pathophysiology yePD zvichaongororwa.

"Dai LoCaMoTE-PD yaizoratidza kuti HBI-002 inokonzera shanduko dzinogona kubatsira muropa iri kana CSF biomarkers, uku ichipa humbowo hwekuchengetedzeka kwakakwana uye kushivirira, izvo zvinogona kubatsira zvikuru kufambira mberi kuchikamu chinotevera chekuedza che2b/3," akadaro Schwarzschild.

Dhizaini itsva iyi inotarisira matambudziko ekutsvaga vanhu, kusanganisira kuzeza kubva kuvarwere neveruzhinji maererano nekuchengetedzeka kwe liquid carbon monoxide. Pachidzidzo cheLoCaMoTE-PD, huwandu hwecarboxyhemoglobin hwakatarwa huri 10% kana pasi, pasi pemuganhu apo migumisiro inowanzobuda (≈15%) uye pasi pehuwandu hunokonzerwa nehupfu hunokonzera njodzi kuhupenyu (>30%). Uyezve, mugadziri akagadzira mushonga uyu nemaune nehuwandu hwakawanda kuitira kuti kunwa huwandu hune chepfu kusazokwanisika nekuda kwekusakwana kwehuwandu hwemudumbu.

Komiti Inotungamira Chidzidzo cheLoCaMoTE-PD nenzvimbo gumi neshanu dzakasarudzwa dzakaita musangano wavo wekutanga paMusangano wePSG muSan Diego pakutanga kwaZvita. Chirongwa ndechekutanga kunyoresa panosvika kupera kwaNdira 2026, uye kupedza kunyoresa panosvika Ndira 2027. Kana zvikabudirira, chidzidzo ichi chine mukana wekuchinja kunzwisisa kwedu kwekudzivirira tsinga muchirwere cheParkinson uye kupa humwe humbowo hwemiedzo mikuru yechikamu chechitatu.