Kubva kumurwere kusvika kutsvagurudzo: Kuongorora mhedzisiro yeprobiotic ine marudzi mana muchirwere cheParkinson

Pfungwa yemuyedzo uyu yakavakirwa pakushanda pamwe chete kwevarwere nevarapi. Muna 2016, mushakabvu Jon Hiseman, mutambi wedhiramu ane mukurumbira webhendi rejazz-rock reColosseum, akataura nesu nezvemukadzi wake, mushakabvu Barbara Thompson, uyo aive nechirwere cheParkinson (PD) uye aive pasi pekutarisira kwedu. Barbara pachake aive mutambi wesaxophone anozivikanwa uye mutungamiriri weParaphernalia, uye akaimba pamhemberero yekutanga kweStockholm MDS Congress muna 2014. Jon akataura kuti Barbara akaona kuvandudzika kukuru mumhedzisiro yelevodopa uye hutano hwake hwese mushure mekutora probiotic ine mhando ina ine Lactobacillus acidophilus, Lactiplantibacillus plantarum, Lacticaseibacillus rhamnosus, uye Enterococcus faecium. Kuona uku kwakaita kuti tiongorore humbowo huripo pamusoro pema microbiota emudumbu uye ma probiotic muPD [1] uye kutsvaga mari yemuyedzo wekiriniki unodzorwa, mushure mekudzidza kwakabudirira kwakaitwa neUniversity College London [2].

Kusashanda zvakanaka kwemudumbu uye kuchinja kwekuzvimba kwemudumbu zviri kuonekwa sezvinhu zvakakosha zvePD, zvichitora matanho ese echirwere ichi, kubva pachirwere cheprodromal kusvika kuchirwere chakanyanya [3,4]. Pfungwa huru yechirongwa ichi yaive yekuti kusashanda zvakanaka kwemudumbu, pamwe chete nezvimwe zviratidzo zvekufamba kwemuviri uye zvisiri zvekufamba kwemuviri (NMS), zvinogona kukanganiswa negut microbiota uye nekudaro zvinogona kugadziriswa zvishoma kuburikidza nekushandisa nzira dzekugadzirisa mudumbu dzakadai semaprobiotics. Kunyange hazvo maprobiotics atoonekwa senzira inobatsira yekurapa kuvimbiwa muPD [3] uye achitsigirwa mukurapa kwePD [5], nzira dzinotsigira mabhenefiti awo akakura hadzisati dzajeka.

Takagadzira uye takaita bvunzo yekurapa ine nzvimbo dzakawanda, isina kurongeka, isina kupofumadzwa kaviri, inodzorwa ne placebo paKing's College Hospital neKing's College London (UK), tichibatsirana neSkåne University Hospital, Lund (Sweden). Varwere makumi manomwe nevana vane PD uye vane kuvimbiwa vakaongororwa zvisina kurongeka kuti vagamuchire mushonga we four-strain probiotic kana placebo nemuromo kwemavhiki gumi nemaviri. Chiyero chikuru chemhedzisiro yaive musiyano wehuwandu hwe gut microbiota taxa pakati pekutanga nevhiki regumi nemaviri mumapoka anoshanda kana e placebo. Mhedzisiro yechipiri yaisanganisira shanduko mumazinga e plasma e inflammatory cytokines. Mhedzisiro yekuongorora yaisanganisira shanduko mu plasma ne faecal short-chain fatty acids (SCFAs), pamwe nekuyera kwe motor ne NMS.

Takaona kuwedzera kwebhakitiriya rine hunhu hunozivikanwa hune chekuita nehutano (kusanganisira Odoribacteriaceae, Enterococcaceae, uye Blautia faecicola) muboka rinoita basa kana tichienzanisa ne placebo. Pamusoro pezvo, huwandu hwe cytokine TNF-α inorwisa kuzvimba muropa hwakaderera mushure mekurapwa ne probiotic. Hapana shanduko dzakakosha dzakaonekwa mumazinga eSCFA. Pakurapa, kudzikira kwenguva yekutora mushonga mushure mekutora levodopa uye muhuwandu hweNMS - zvichikonzerwa nekuvandudzika kwekuzvimba uye kuneta - kwakaonekwa muboka rinoita basa.

Zvakawanikwa muongororo yeSymPD zvinoratidza kuti iyi probiotic ine marudzi mana inogona kugadzirisa zvakanaka hutachiona hwemudumbu, zvichikonzera migumisiro pakuzvimba kwemuviri, nguva yekupindura kwelevodopa, uye mutoro wezviratidzo zvisiri zvemuviri muvarwere vane PD uye kuvimbiwa. Izvi zvinotsigira kuferefetwa kwakawanda kwemaprobiotics senzira itsva yekurapa chirwere cheParkinson.

References

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