BHUKU 29, CHIKAMU 4 • ZVITA 2025.
Kufanotaura chirwere cheα-synuclein mushure mekufa nekuvapo kweREM sleep behavior disorder pamwe chete nehyposmia
Pachinzvimbo chevanyori vese, tinotenda zvikuru Movement Disorder Society nekutipa mibairo iyi. Movement Disorder Clinical Practice (MDCP) Research Paper of the Year Award nekuda kwepepa redu rakaburitswa rine musoro unoti “Kufanotaura Mushure mekufa α-Synuclein Pathology neCombined Presence of Probable REM sleep behavior disorder and Hyposmia.”
Chinangwa chedu chebasa iri kwaive kupa rubatsiro rwenzira iri nyore yaizovandudza kuzivikanwa kwevanhu vane progressive neurodegenerative α-synucleinopathy. Pasinei nekufambira mberi kukuru mukugadzirwa kwe biomarkers in vivo, zvichiri dambudziko guru kuziva vanhu vane chirwere cheParkinson (PD) kana dementia vane Lewy bodies (DLB), kunyanya pakutanga kwechirwere. Kuongororwa kwekutanga kwakakosha pakugadzirwa kwemishonga inochinja chirwere iyo inogona kudzivirira kuremara kunopfuurira kunoparadza hupenyu hwakawanda.
Hyposmia, kunzwa kushoma kwekunhuhwirira, chiratidzo chinonzwisisika uye chiratidzo chine simba chePD neDLB. Pamusoro pezvo, idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), chirwere cheparasomnia chinoratidzwa nemaitiro ekurota uye kurasikirwa neREM atonia, chiratidzo chinozivikanwa chekuongorora kwekupedzisira kwekiriniki kunosanganisira α-synuclein pathology, kusanganisira PD, DLB, uye multiple system atrophy. Kuyedzwa kwekuzivikanwa kwekunhuhwirira kunonyanya kufarirwa sezvo kuchidhura zvishoma uye kuri nyore kuita. Pamusoro pezvo, nepo kuongororwa kweRBD kwakajeka kuchida video-polysomnography, zviyero zvinodhura uye zvinotora nguva, RBD inogona kuongororwa nenhoroondo uye nerubatsiro rwemibvunzo yekuongorora yakasimbiswa.
Mubasa iri, takavavarira kuongorora kukosha kwe hyposmia pamwe chete uye kuongororwa kwechirwere cheRBD chinobvira pakufa kwechirwere cheLewy type α-synucleinopathy muuropi mushure mekufa. Kuti tiite izvi, takashandisa data kubva kuArizona Study of Aging and Neurodegenerative Disorders (AZSAND) uye takaongorora vanhu vanosvika 652 vakapedza bvunzo dzekufamba nepfungwa, kuongororwa kweRBD inobvira uye bvunzo yekuzivikanwa kwemunhu anenge afa uye kuongororwa kwechitunha.
Zvakabuda muongororo yedu zvinoratidza kuti kunzwisiswa kweRBD pakufanotaura α-synucleinopathy kwaive 38.8% uye kunzwisiswa kwe 88.8%, nepo kunzwisiswa kwe hyposmia kwaive 74.4% uye kunzwisiswa kwe 73.4%. Pakubatanidza zviyero zvese izvi, kunzwisiswa kwe 34.3% uye kunzwisiswa kwakawedzera kusvika 97.2%.
Zvatakawana zvikuru zvinoratidza kuti kusanganiswa kwe hyposmia ne RBD inogona kunge yakanyatsojeka pakufanotaura kuvapo kwe α-synuclein pathology mushure mekufa, uye vashoma vane positives dzenhema. Nzira iyi inogona kupa nzira inodhura uye iri nyore yekufanotaura pathology yemuviri weLewy munharaunda yakakura. Iyi ndiyo ongororo yakakura kwazvo yekiriniki kusvika pari zvino inoongorora mubvunzo uyu. Mhedzisiro iyi inosimudzira munda mberi nekusimbisa hukama hwakaratidzwa mukiriniki pakati pe Lewy pathology, RBD, uye hyposmia kuburikidza nehumbowo hwekiriniki hwakasimbiswa neuropi.
Tinotenda zvikuru vese vatori vechikamu nemhuri dzavo nekuzvipira kwavo. Tinotendawo vashandi vese veAZSAND vakatora chikamu mukuedza kwemakumi emakore kwaidiwa kuunganidza ruzivo rwekiriniki nerwezvirwere zvakashandiswa muchidzidzo ichi.
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