Migumisiro yeprobiotic pazviratidzo zvechirwere cheParkinson

Dr. Valentina Leta inyanzvi yezvetsinga dzemuviri uye muongorori ane hanya nekushanda zvisina kunaka kwemudumbu muParkinson's, uye parizvino anoshanda kuInstituto Neurologica Carlo Besta muMilan, Italy. Uye Dr. Ray Chaudhuri ndiye Mutungamiriri weKutsvagisa neKuedza kweKliniki paKing's College Hospital, London muDubai United Arab Emirates, pamwe chete napurofesa weKing's Parkinson's Center of Excellence muDubai, uye purofesa paDement Tech Neuroscience Clinical Academic Center muLondon.

Tichataura nezve [00:01:00] chinyorwa chavo chachangobva kubuda muMovement Disorders Journal, Effects of Four Strain probiotic on Gut Microbiota, Inflammation and Symptoms in Parkinson's Disease. Uye iyi yaive bvunzo yekiriniki yakaitwa nemaitiro asina kurongeka.

Kana vateereri vedu vasati vatozviita, ndinokurudzira kuti mudzokere kuchikamu 111 cheMDS Podcast, chinova chikamu cheHot Topic pamusoro pe microbiome yemudumbu muchirwere cheParkinson.

Uye izvi zvine chekuita nehurukuro yatichaita nhasi. Tichatanga newe Ray. Ndinoda kuti utiudze kwakabva chidzidzo ichi. Zvakafungwa sei?

Dr. Kallol Ray Chaudhuri: Tatenda Sara, nekutigamuchira papodcast iyi. Ndafara kuva pano naValentina. Ehe. Basa iri rakatangwa kuburikidza nekuona zviri mberi uye ruzivo rwemurwere wangu akafa nguva pfupi yadarika, asi aive neParkinson's uye aive neParkinson's kwemakore mazhinji.

Uye akaverenga nezvematumbu nematambudziko e [00:02:00] microbiota makore mazhinji apfuura uye akandibvunza kana achifanira kuedza kushandisa mamwe ma probiotics anoshanda pa microbiota, uye akawana iyi probiotic chaiyo uye anga achiishandisa uye akauya kwandiri achiti kubva paakanga achitora iyi probiotic chaiyo, akanzwa zviri nani zvikuru.

Anzwa simba rakawanda uye akati akakwanisa kufamba netsoka kuenda kukiriniki yangu kekutanga izvo zvaakanga asati ambokwanisa kuita. Izvi zvinogona kukonzerwa nezvinhu zvakawanda, asi akati izvi zvinokonzerwa nesimba nesimba raaiva naro kubvira paakatanga kushandisa symprove. Uye izvi zvakatsigirwa nemurume wake, uyo akabva andikumbira kakawanda kuti ndione, sei usingaedze? Sei usingaedze? Saka izvozvo zvakaita kuti ndikurukure nezvechirongwa ichi nevanogadzira symprove, avo vandakataura navo uye vaida kwazvo kuzviisa mumuedzo wakaoma [00:03:00]. Ndizvo zvatakasvika pamuedzo.

Uye zvechokwadi, Valentina ndiye akazotungamira mukuyedzwa uku, uko takazokwanisa kuwana mari kubva kwazviri kuti tiite bvunzo iyi. Saka ndinofunga uyu muenzaniso chaiwo apo ruzivo rwakavakirwa pamurwere rwakakonzera kuumbwa kwekuyedzwa kwenyika dzese kunodzorwa nedoubleblind placebo. Uye ipapo data rinotevera ratichakurukura.

Saka nhoroondo inonakidza zvikuru kuti ruzivo rwemurwere rungave rwakakosha sei kwatiri kuti tigadzire kana kutofunga nezvemiedzo yekiriniki yemamorekuru kana zvigadzirwa zvavangawana zvichibatsira.

Dr. Sara Schaefer: Ndicho chinangwa chikuru, chekupedzisa nemurwere uye ndinofarira kuti uri kutangawo nemurwere. Valentina, ungatitsanangurira muchidimbu zvinozivikanwa nezvechirwere chekutanga cheParkinson, uye chikonzero chekushandisa mapurobiotics muvanhu ava.

Zvidzidzo zvemhuka nevanhu zvakaratidza chii kusvika pari zvino usati watanga kudzidza nezve [00:04:00]?

Dr. Valentina Leta: Mazvita Sara, zvakare nekutigamuchira pano. Uye hongu, pamwe unoziva kuti munguva pfupi yapfuura nhau idzi dzekupatsanura type dzakakurudzirwa chirwere cheParkinson. Muviri kutanga uchipesana neuropi kutanga neParkinson's disease. Saka muuropi kutanga takafungidzira kuti chirwere ichi chingatanga mwero we central nervous system, substantia nigra nekukura kweParkinsonism, uye chirwere ichi chingapararira ku brainstem nekukura kweRBD uyezve ku peripheral nervous system nezvimwe zviratidzo zvisiri zvekufamba zvakaita se orthostatic hypotension ne constipation. Kunyange zvazvo muviri uchitanga neParkinson's disease, chirwere ichi chingatanga padanho re peripheral nervous system pakutanga ne constipation ne orthostatic hypotension se prodromal feature uye chozopararira ku brainstem ne locus [00:05:00] uye kuva ne prodromal RBD uye chozokanganisa substantia nigra nekukura kweParkinsonism. Iye zvino pane zvipingamupinyi zvakawanda kune iyi modhi zvinonyanya kubva muzvidzidzo zve postmortem. Tinogona kuona izvi zvekiriniki mukiriniki yedu.

Kune vamwe varwere vane zviratidzo zvakasiyana-siyana zve prodromal nonmotor uye vamwe varwere vasingaratidzi zviratidzo zve nonmotor vasati vatanga chirwere che classic Parkinsonism. Zvino kana tikanyanya kutarisa pamuviri kutanga chirwere cheParkinson. Kutaura zvazviri, rudzi urwu runogona kunge rwakatanga kupinda mudumbu.

Uye tinoziva kuti kusashanda zvakanaka kwemudumbu kunowanzoitika muvarwere vane chirwere cheParkinson. Semuenzaniso, kuzvimba chimwe chezvinhu zvinokonzera kukura kwechirwere cheParkinson. [00:06:00] Uye izvi zvakagadzira nzvimbo yekuferefeta nezve microbiota yemudumbu muvanhu vane Parkinson. Microbiota yemudumbu iboka remabhakitiriya, fungi, mavhairasi, mapuroteni, anogara mudumbu medu, uye akakosha zvikuru kuhutano hwevanhu. Anogona kugadzirisa metabolism, anogona kugadzirisa mashandiro emudumbu. Anogona kugadzirisa kuzvimba, neurotransmission, uye zvinhu izvi zvinochinjwawo muchirwere cheParkinson.

Patine chirwere chinodzivirira kuzvimba, tinoziva kuti chirwere ichi chinokanganisa kwete dopamine chete, asiwo serotonin, acetylcholine, nezvimwewo. Uye tinewo dambudziko remudumbu rinobuda. Saka mamiriro ezvinhu apo mucosa yemudumbu inowedzera kupinda. Iye zvino zvidzidzo zvakasiyana-siyana zvakatarisa [00:07:00] pa microbiota yemudumbu muvarwere vane chirwere cheParkinson.

Uye chaizvoizvo chinhu chinowanzoonekwa ndechekuti chirwere chinodzivirira kuzvimba uko kuzvimba kunogona kukonzera alpha synuclein pathology. Uye pakati pekuchinja kwakasiyana-siyana kwakaitwa, pane kudzikira kwehuwandu hwebhakitiriya rinogadzira fatty acid muchikamu chidiki. Mafatty acids muchikamu chidiki ndiwo metabolites, ayo anobatsira nekuti anoderedza kuzvimba, uye aya ndiwo anoshandiswa pakushandisa nzira dzekugadzirisa gut microbiota muchirwere cheParkinson, kusanganisira probiotics. Izvo zvinotsanangurwa neWHOS live microorganism, iyo inogona kupa mhedzisiro inobatsira kune munhu wacho.

Dr. Kallol Ray Chaudhuri: Kana ndikangokwanisa kuwedzera chirevo chimwe chete pane pfungwa dzaValentina dzekuti muviri kutanga, uropi kutanga [00:08:00] zvakatorwa kubva patsananguro yaSour Beer etal muna 2015. Kwatakabatanidzwa mumidzi mitatu yakatsanangurwa, mumwe waiva brainstem, mumwe waiva limbic, mumwe waiva cognitive kana neocortical.

Uye kutaura chokwadi, muviri unotanga wava nechimiro che limbic ne brainstem approach. Uye kutaura chokwadi, zvakatsanangurwawo kuburikidza nema neurotransmitters, uye ini naValentina, tese takatsanangura rudzi rwe noradrenergic, runopindirana nefungidziro dzekutanga dzemuviri, asi chinhu chikuru ndechekuti ura hahuna kushanda zvakanaka, sezvakataurwa naValentina. Chinangwa chechirongwa ichi chaive chekuona kana izvozvo zvingagadziriswa nekushandisa chinhu chisiri chemishonga, chinopinda muura hukuru.

Dr. Sara Schaefer: Uye Ray, ndinoshamisika kana ungatsanangura zvishoma pane zvakaratidzwa mumhuka nevanhu maererano nekushandiswa kwe [00:09:00] kwemishonga yekudzivirira hutachiona yeParkinson's kana Parkinson's.

Dr. Kallol Ray Chaudhuri: Ehe, saka kune mabasa akawanda ekugadzirira kurapwa aripo, kunyanya mukurapa kwechirwere chepfungwa, uye Valentina anogona kuwedzerawo pane izvozvo, mumakonzo anoratidza kuti microbiota inogona kupfuma zvakanyanya nemamwe mabhakitiriya anodzivirira nekushandisa symprove. Izvi zvakaratidzwa mumamodheru ezvirwere zvemudumbu zvinoputika uye semuenzaniso muboka rechirwere chepfungwa uye pamwe mu irritable bowel syndrome. Uye takaburitsawo pamwe chete neboka rekugadzirira kurapwa paYunivhesiti yeLondon.

Takaburitsawo ruzivo rwakafanana nerwemakonzo aya rwakabatsira pakuwedzera gutmicrobiota uye pamwe Valentina, unoda kutaura zvakawanda nezvazvo here?

Dr. Valentina Leta: Ehe, ndatenda Ray. Ehe chaizvo [00:10:00] maererano nechirwere cheParkinson, takaongorora nyaya iyi tisati tatanga chidzidzo ichi, uye tinoziva kuti kubva muzvidzidzo zve preclinical, kushandiswa kwema probiotics kungave neproperties yekudzivirira tsinga, kunyanya zvakaratidzwa kuti ma probiotics anogona kuwedzera neurotrophic factors, mazinga padanho re central nervous system, asiwo dopaminergic neurons mu substantia nigra yemhando dzemhuka dzechirwere cheParkinson.

Dzinogona kunge dziine simba rekudzivirira kuzvimba uye rekudzivirira muviri padanho retsinga huru uye padanho remuviri. Uye chekupedzisira, kana tikaongorora zviratidzo zvekufambisa nekushanda kwemuviri, kushandiswa kweprobiotic kwakabatana nekuvandudzwa kwekufamba kwemuviri uye kushaya ndangariro pakati pezvimwe zvinhu zvisiri zvekufambisa muviri mukushanda kwemuviri kweParkinson's.

Zvisinei, [00:11:00] kana zvasvika pakudzidza kwekiriniki, zvakawanikwa izvi zvakangoshandurwa zvishoma uye kutaura zvazviri, panguva ino, tine humbowo hwepamusoro chete hwekushandiswa kwemaprobiotics kugadzirisa kuvimbiwa muvanhu vane chirwere cheParkinson.

Dr. Sara Schaefer: Saka tichitarisa zvese zvatinoziva kusvika pari zvino, wakagadzira sei chidzidzo chako uye wakaona mhedzisiro ipi? Valentina.

Dr. Valentina Leta: Takasarudza kuita bvunzo yakarongwa ye double blind placebo controlled trial tichiongorora mhedzisiro yeiyi mhando ina ye probiotic pakugadzirwa kwe gut microbiota pazviratidzo zve inflammatory mudumbu nemuviri pamwe nezviratidzo zve motor ne nonmotor zve Parkinson's disease. Takashandisa murwere makumi manomwe nemana ane Parkinson's disease uye abstinence nekuti taida kutarisa chidzidzo chedu pavarwere [00:12:00] neuchapupu hwakajeka hwekubatanidzwa kwemudumbu.

Uye vatori vechikamu vakagoverwa kumapoka maviri, boka revari kushanda uye boka re placebo, uye vakateverwa kwemwedzi gumi nemiviri. Saka takava neongororo yekutanga uye yemavhiki gumi nemaviri, yakavakirwa pahuwandu hwezvikero zvakabvumidzwa uye mibvunzo yezviratidzo zvekufamba kwemuviri uye zvisiri zvekufamba kwemuviri. Takaunganidzawo sampuro dzetsvina neropa kuti tiite, kuongorora sampuro idzi dzemuviri. Uye zvakanyanya takasarudza kutarisa kushanduko dzema microbiota emudumbu, izvo zvaive mhedzisiro yedu huru. Zvadaro mhedzisiro yechipiri. Takaongorora shanduko muzviratidzo zvemuviri nekunze kwekuzvimba, uye pakupedzisira taida kuongorora mhedzisiro inogona kubatsira yeiyi probiotic pazviratidzo zvekufamba kwemuviri uye zvisiri zvekufamba kwemuviri, izvo zvaimiririra mhedzisiro yedu yekuongorora [00:13:00].

Dr. Sara Schaefer: Wakawanei?

Dr. Valentina Leta: Saka chekutanga, takaona kuti mapoka maviri aya aive akaenzana zvakanyanya maererano nehuwandu hwevanhu, zviratidzo zvekiriniki, uye zviyero zvekusiyana kwezvirwere zvemudumbu. Izvo zvaive zvakanaka kwazvo nekuti zvinoreva kuti kusarongeka kwakabudirira uye mapoka maviri aya aive akafanana. Uye kutarisa pane chiyero chekutanga chemhedzisiro.

Hatina kuona shanduko huru pakati pemapoka maererano ne alpha ne beta diverse metrics, zvinoreva kuti kupindira hakuna kuchinja zvakanyanya hutachiona hwemudumbu hwevanhu ava. Izvo zvakakosha nekuti hatina kuda kuchinja zvakanyanya hutachiona hwemudumbu, asi kupindira kwakanangwa kunofanira kuchinja mamwe maitiro kana mashandiro. Saka nekuongorora kwakawanda [00:14:00], takaona kuti kupindira kwakasimba, probiotic, kwakabatana nehuwandu hwakawanda hwemabhakitiriya, anozivikanwa zvikuru kuva nehupfumi hunobatsira hwakadai semabhakitiriya, mhuri yeOdoribacteriaceae, inozivikanwa kuti inobatanidzwa nekukwegura kwakanaka.

Kana semuenzaniso, Blautia faecicola, inova bhakitiriya inoburitsa mafuta acid muchikamu chidiki, inozivikanwa kuti inoderera muvarwere vane Parkinson's. Saka izvi zvaive mhedzisiro inonakidza. Uye takatarisa mhedzisiro yechipiri. Takawana kudzikira kwakakosha kwe cytokine TNF-α inorwisa kuzvimba uye tichitarisa mhedzisiro yekutsvaga, paive nezviratidzo zvakanaka zvekuderedza mutoro wezviratidzo zvisiri zvemuviri, izvo zvatinoziva kuti zvine chekuita nehupenyu hwemunhu.

Uye izvi zvaikonzerwa nekuvandudzika kwekuzvimba uye kuneta, izvo zvaifadza kuona.

Dr. Sara Schaefer: Saka tichitora ruzivo urwu rwese, makandipa runyorwa rwakakura rwezvinhu zviri kuchinja muma probiotics muvanhu ava. Munofunga kuti chii chiri kuitika pathophysiologically? Ma probiotics ari kuita sei chaizvo kubatsira varwere?

Dr. Valentina Leta: Saka ndinotenda kuti tsananguro inonzwisisika inogona kunge iri yekuti nekushandisa ma probiotics tinogona kuvandudza kuvimbiwa. Saka tinogona kuderedza chipingamupinyi ichi pakufambiswa nekunyudzwa kwemushonga wepamusoro weParkinson's disease, iyo inonzi oral levodopa. Saka nekutora levodopa iri nani, tinogona kuderedza nguva yekuenda kuON, izvo zvaive chimwe chinhu chatakaona. Saka nguva yemushonga kutanga, kutanga uye zvimwe zvinhu zvisiri zvemotor zvinogona kunge zviri dopaminergic [00:16:00]. Imwe tsananguro inogoneka, iyo iri yekufungidzira zvishoma, ndeyekuti ma probiotics anogona kuderedza kuzvimba kwemudumbu nekuchinja gut microbiota, uye izvi zvinogona kukonzera kudzikira kwesystemic inflammation status, uye izvi zvinogona kutungamira mukuvandudzwa kwezvimwe zviratidzo zvisiri zvemotor zvakaita sekuneta, izvo zvinozivikanwa kuti zvine chekuita nekuzvimba, zvishoma. Asi izvi zvinoramba zviri zvekufungidzira zvishoma sefungidziro.

Dr. Sara Schaefer: Zvese izvi zvinonzwika setariro huru yekuti panogona kuva nekuvandudzika kukuru, kwete chete muzviratidzo zvisiri zvekufamba kwemuviri, asi kunyange mune zvimwe zviratidzo zvekufamba kwemuviri muvarwere ava. Saka uri kumhanyira kukiriniki yako kunoudza varwere vako vese kuti vatange mishonga inorwisa mabhakitiriya here kana kuti unofunga kuti izvi zviri kushandurwa sei munzvimbo yekurapa panguva ino?

Dr. Kallol Ray Chaudhuri: Ndinofunga kuti izvi zvava [00:17:00] maitiro emunhu ega, emunhu oga ekunyora mishonga mune vanachiremba vakasiyana nevashandi vehutano. Mukurapa kwangu, takatsanangura uye takaburitsa padashboard yeParkinson, inova imwe yemitemo yekutanga inofanirwa kuzadzikiswa uye kuvandudza hutano hwemudumbu ndeimwe yacho.

Kugadzirisa kuvimbiwa, kugadzirisa kunyudzwa kwelevodopa nekuderedza kudyiwa kwemukaka ne levodopa, nezvimwewo. Uye ndinofunga kuti meseji yekudzokera kumba kubva mukuyedzwa uku uye bvunzo yakaitwa zvakasimba, double-blind placebo controlled trial, ndeyekuti zvinoita sekunge ma probiotic mana ari pano anoita seanovandudza nguva yako yekuenda kuON.

Saka kana zvakadaro, ndinowanzo tora mishonga yekurapa varwere vakaneta. Ndiri kutokumbira kuti vatore mishonga yekurapa, mukana wekuwedzera uyu uri pano muUK, pamwe muEurope nemuUS zvakare, kuti haisi mushonga we [00:18:00]. Saka unogona kuva nayo usingashandise mishonga zvakanyanya semuenzaniso, varwere vazhinji vanotora mishonga yekuwedzera, varwere vazhinji vanotora mavhitamini, nezvimwewo, uye mamwe ma probiotics kubva kuzvitoro zvikuru, masupamaketi nezvimwewo. Saka varwere vanogona kushandisa iyi mishonga yekurapa. Uye tichifunga nezve data, inobatsira nguva yekuenda kuON iyo ichava nemhedzisiro yakajeka yekufamba kwemuviri. Asi pamusoro pezvo kuvandudzwa kwezvinhu zvisiri zvekufamba kwemuviri kunokurudzira zvikuru.

Kuvimbiwa kwacho, kuneta kwacho. Uye izvi zvinodzokera kutsananguro yemurwere wekutanga. Chimwe chezvinhu zvikuru zvaakandiudza tisati tataura nezvemuyedzo uyu ndechekuti paakatanga kushandisa mushonga wekubatsira, zvakamubatsira kuneta kwake, zvakamubatsira kunzwa zvakanaka, izvo zvandinofunga kuti pamwe ndizvo zvaaitsanangura kuneta kwacho.

Saka zvinofadza kuona kuti izvi zvakaratidzwa mudata rakabva muongororo yaValentina. [00:19:00] Asiwo mumaonero angu, zvisinei, kuti chigadzirwa chinokurudzirwa pakutanga kana kunyange pakupera kwechirwere cheParkinson's, chero bedzi paine kupera simba. Hazvina kuipa kuedza, kunyanya, zviri kuvandudzawo hutano hwemudumbu.

Uye sezvinoratidzwawo nedata kuti kune imwe nzira yekudzivirira kuzvimba, iyo inoita seinokurudzira zvikuru nedata re cytokine ratiinaro.

Dr. Sara Schaefer: Chero chinhu chine ruzivo rwekutsigira kushandiswa kwacho pakuneta muParkinson's chinowedzera zvakanaka kune zvatinodya, handiti? nekuti izvozvo zvakaoma kurapa kunze kwekunge paine chimwe chinhu chiri kuitika, senge sleep apnea kana low blood pressure. Kana wangobvisa zvese izvozvo, hapana zvakawanda zvatinazvo mubhokisi redu rezvishandiso.

Zvakanaka kuti izvi zvingave chimwe chinhu chekufunga nezvacho. Zvino, Ray, unoramba uchitaura kuti iyi imhando imwe chete yemhando ina dzeprobiotic, asi sezvatinoziva tese, kune akawanda maprobiotics kunze uko, makambani mazhinji [00:20:00], akawanda maformulations, nezvimwewo. Sei iyi probiotic yakasarudzwa kunze kwekuti murwere uyu akakuratidza kuti iyi ndiyo yaaive nayo?

Uye ungakurudzira sei mupi wemishonga anorapa varwere veParkinson kana munhu ane Parkinson kuti apinde mugungwa remaprobiotics aanofanira kusarudza kubva?

Dr. Kallol Ray Chaudhuri: Mubvunzo wakanaka, Sara. Ndinofunga, chinhu chakakosha kuziva pano ndechekuti pandakangopihwa ruzivo, ini naValentina, takatanga sezvawataura, tichitarisa humbowo hwatovapo. Uye takaona kuti iyi probiotic yemhando ina yakamboshandiswa mune zvimwe zvirwere, kwete chirwere chetsinga, asi muzvirwere zvemudumbu. Uye zvakare kune humbowo hwakanaka hwekuti iyi inoshandiswa kare muzvirwere zveClostridium difficile, uko musiyano neiyi probiotic chaiyo [00:21:00] ndeyekuti ine kupinda kwakanaka mudumbu guru uye mu microbiota, izvo zvaunoita seusingazviwani nemamwe ma probiotics akawanda.

Zvingangodaro kuti pangave nemamwe ma probiotic anokwanisa kuita izvozvo, asi hatina humbowo hunotsigira izvi. Saka chikonzero chatakasarudza kuvandudza iyi probiotic ndechekuti tine humbowo hwekuti kushanda kwayo muboka reClostridium difficile, taive neruzivo rwekushanda kwayo kubva muzvidzidzo zve preclinical mu inflammatory bowel disorders pamwe neruzivo rwekutanga rwevarwere veParkinson vachiti vanonzwa zviri nani nayo.

Saka ndiyo yaive simba rakaunganidzwa, kana uchida, rakatisvitsa pairi. Valentina, unoda kuwedzera pane izvozvo here?

Dr. Valentina Leta: Kungoti chimwe chezvinhu zvinonyanya kukosha kuti probiotic ishande ndechekurarama munzvimbo ine acid mudumbu. Uye pane chidzidzo che in vitro [00:22:00] apo muongorori, vaitevedzera nzira yekugaya chikafu ne acid yemudumbu, uye iyi yaive imwe yema probiotic mashoma akakwanisa kurarama munzvimbo ine acid yemudumbu ne types dzekuva mupenyu. Saka izvi zvakakosha. Uye zvakare, ngatisakanganwe humbowo hwe preclinical pamusoro pekushandiswa kwe probiotic iyi chaiyo mumhando dzemhuka dzeParkinson's. Izvi ndizvo zvakambotaurwa naRay. Saka paive nezvakawanikwa preclinical uye clinical, izvo zvakatitungamira pakusarudzwa kweiyi probiotic ine mhando ina chaiyo.

Dr. Sara Schaefer: Izvozvo zvinobatsira zvikuru. Valentina, wataura zvechokwadi, kuti pakudzidza uku wakasarudza varwere vane kuvimbiwa uye chirwere cheParkinson. Zviri pachena kuti GI inobatanidzwa. Ndinoshamisika kana muchifunga kuti pangave nevarwere [00:23:00] kunze kweboka diki iro rinogona kubatsirwa nekuda kwezvinhu zvinodzivirira kuzvimba, kana kuti tinogona here kufunga kuti varwere vane kuvimbiwa chete ndivo vane zvirwere zvemudumbu muchirwere cheParkinson?

Dr. Valentina Leta: Waita basa Sara nekutaura pfungwa iyi inokosha. Pane humbowo hunoratidza kuti kunyangwe munhu ane chirwere cheParkinson asina kuvimbiwa anogona kunge aine zvimwe zvirwere zvemudumbu. Ivo, tupukanana twavo twemudumbu vanogona kuchinjwawo. Saka chokwadi kunyangwe kana kuvimbiwa kusina, panogona kunge paine zvimwe zvirwere zvemudumbu.

Zvisinei, tinofanira kuva nehumwe humbowo hunoratidza kuti hutachiona hwemudumbu hunokanganisa hutachiona muboka iri revarwere nekuti panguva ino tinoziva kuti hunogona kubatsira pakudzivirira kuvimbiwa. Uye pane zvimwe zviratidzo zvakanaka zvatataura.

Danho rinotevera ringave [00:24:00] kugadzira miedzo mikuru yekiriniki, kutarisa zvinhu izvi zvemota uye zvisiri zvemota kuti zvisimbise zvakawanikwa pakuongorora uku, uye pamwe kukwanisa kupa mapurobiotic kuvarwere vane kuchinja-chinja kwenguva inononoka kusvika paON kana kuneta.

Zvino tinofanira kusimbisa zvakawanikwa izvi zvekutsvaga.

Dr. Kallol Ray Chaudhuri: Ehe. Kutaura zvazviri, tiri kuita izvi naValentina neni, tiri kuedza kuunganidza zita rakavhurika, chidzidzo chehupenyu chaihwo munzvimbo dzakawanda pasi rose nekuti tinodawo kutarisa marudzi akasiyana, tsika dzakasiyana, kudya kwakasiyana, mhando dzakasiyana dzekudya. Ruzivo urwu runoshanda sei kuvarwere vekuAsia, kuvarwere vatema vemuAfrica kana zvakadaro, nezvimwewo.

Saka tinoda kuita ongororo yakakura kwazvo yemarudzi akasiyana-siyana, kungori ongororo yekushivirira, asi pamwe kugadzirisa, sezvamakataura, Sara, [00:25:00] kuneta. Izvo zvinhu zvinotinetsa zvikuru. Vanhu vane Parkinson's, uye kune isu tiri muchikamu chekurapa. Saka tinoda kuita chimwe chinhu chakadaro.

Dr. Sara Schaefer: Zvakanaka, ndinotarisira matanho anotevera uye data rinotevera. Mune mashoko ekugumisa here pakati penyu?

Dr. Valentina Leta: Ndinotenda kuti iyi inzvimbo inoda kuongororwa zvakanyanya. Kune. Humwe humbowo hwakasimba hunoratidza kuti gut microbiota ine basa guru muhutano hwevanhu nezvirwere zvakaita seParkinson's diseases. Saka zvakakosha kuti tiongorore zvakanyanya kushandiswa kwegut microbiota modulating intervention kuti tione zvakajeka kukanganisa kunogona kuita izvi pazviratidzo zvemota nemota zveParkinson's disease uye kuti tinzwisise kuti ndeapi maitiro anotsigira izvi zvinogona kubatsira.

Dr. Kallol Ray Chaudhuri: Ndinotsigira izvozvo zvizere. Asi ndinodawo kuwedzera kuti [00:26:00] zvinonakidza kuti Movement Disorder Society, pamwe chete neboka rekudzidza nezveutano muParkinson, rinotungamirwa naIdu Subramanian nevamwe vake. Uye hutano hwezvinhu zvikuru zvinobatsira hutano hutano muParkinson's.

Saka tinofunga kuti iri idanho rakakosha zvikuru rekuti nekushandisa mushonga usiri wekurapa, wakachengeteka, watinoshandisa uye vazhinji vedu tinobatsira zvikuru pakurapa, kana muchida. Vazhinji vedu tiri kushandisa mishonga yekuwedzera hutano hwemudumbu kunyangwe musina chirwere cheParkinson's. Saka kuwanikwa kwemushonga wakadaro, uyo wakavakirwa pauchapupu hwakanaka, ikozvino humbowo hwekutanga kutsigira iwoyo ingori danho rekufambira mberi kune pfungwa yese yehutano muParkinson's mune ramangwana.

Uye tinotarisira zvikuru kuti chidzidzo chedu chepasi rose chichawedzera kusimbisa ruzivo urwu.

Dr. Sara Schaefer: Zvinoshamisa izvozvo. Ndanga ndisingazive [00:27:00] nezveboka iroro rekudzidza, asi ndinonzwa sekuti ndinoda kuva naro. Maonero akazara emurwere uye kufunga nezvehupenyu hwakanaka. Ndinoda maonero iwayo. Tinokutendai zvikuru mese nekubatana nesu nhasi uye kugovana zvabuda izvi nesu.

Dr. Kallol Ray Chaudhuri: Ndatenda zvikuru uye ndatenda, Valentina nebasa rako rese.

Dr. Valentina Leta: Ndatenda, Ray, nekupa mazano kwako. [00:28:00]